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CROSPOVIDONE is a cross-linked polyvinylpyrrolidone, which is mostly used as a clarifier and stabilizer for beer, fruit wine, and fruit juice in the brewing and beverage industries. It improves the stability of beer while maintaining the characteristics and flavor of beer, such as the basic qualities of the beer, flavor, and foam stability.
Crospovidone cas number: 9003 39 8
Clarifier and stabilizer
Crospovidone is a polymer that is insoluble in water, strong acid, strong alkali and general organic solvents formed by the polymerization of NVP under specific conditions. This insoluble PVPP is used to absorb polyphenols in beer without leaving any residue in the beer. It can be used safely and effectively. Therefore, PVPP can be used as a clarifier and stabilizer for beer, fruit wine and fruit juice in the brewing and beverage industries.
Pharma excipients
Crospovidone is often combined with active ingredients in medications and dietary supplements to allow absorption of the active drug. It is considered a synthetic povidone analog. Chemically, crospovidone is an inert and insoluble white to light yellow free-flowing powder. It has hygroscopic, or water-attracting properties with excellent swelling characteristics. It is this swelling characteristic that makes it useful as a disintegrant in pharmaceutical dosage forms.
PVPP is a highly efficient disintegrant that can make all excipients swell at the fastest rate. Its unique spherical particles allow it to be evenly dispersed in tablets and have a larger surface area/volume ratio than other disintegrants. Its open amorphous structure allows it to swell rapidly in all directions in the presence of any body fluid, generating a high internal stress that promotes tablet disintegration.
PVPP can effectively remove anthocyanins and improve the stability of beer while maintaining the characteristics and flavor of beer, such as basic qualities such as quality, flavor, and foam stability. Currently, countries around the world have adopted PVPP adsorption filtration as a beer stabilization treatment.
When used in skin care products, PVPP is much better than any drug used before. It has a significant effect on skin inflammation, erythema and acne, especially in terms of analgesia and irritation reduction.
Monographs define crospovidone into two broad particle size types: A (coarser than 50 μm) and B (finer than 50 μm). For crospovidone, a wicking agent, particle size relates to particle porosity. As size increases, the intraparticular porosity increases as well leading to larger water uptake and faster disintegration. A more thorough consideration of crospovidone type A VS type B particle size specifications could be beneficial.
