Povidone in the Medical Field

PVP can be used as a binder for tablets and granules, a solubilizer for injections. Stabilizer, dispersant for liquid preparations, coating film-forming agent and pigment dispersant, co-precipitant for poorly soluble drugs, and delay agent and lubricant for eye drops, etc.

As a binder: Drug tablets should have a certain mechanical strength so that they will not break when subjected to inevitable impact and friction during production, transportation, packaging and sales. At the same time, they are also required to disintegrate quickly in the digestive tract and release drugs after taking them. PVP with strong solubility can fully meet the above requirements.

As a co-precipitant: Many drugs have good efficacy, but their bioavailability is reduced due to their low solubility in water. Using certain water-soluble carriers to co-precipitate with drugs can increase the dissolution rate of drugs, improve efficacy and reduce dosage. PVP is the best choice.

As a solubilizer or dispersion stabilizer: PVP can be used as a solubilizer or crystal growth inhibitor in injections.

As a coating film-forming agent: Adding PVP to the film coating can not only increase the adhesion of the coating to the drug base, but also increase the stability of the coating suspension due to its excellent dispersibility, avoiding the reaggregation and migration of pigments.

As an ophthalmic adjuvant: Adding a certain amount of PVP to eye drops can reduce the irritation of the drug to the eyes, increase the viscosity, prolong the action time of eye drops in the eyes, and can also serve as artificial tears.