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Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone from Huzhou Sunflower Specialty Polymer Co.,Ltd. is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.
Copovidone is generally regarded as nontoxic. However, oral consumption of excessive quantities may produce stomach upset. It has not been shown to be sensitizing to the skin. Animal studies in rats and dogs do not show significant toxicity with high dietary levels.
Long-term stability
PVP/VA64 copolyvidone Dry binder in direct tableting and dry material preparation processes.It is an is a spray-dried powder with good fluidity and can be mixed very evenly with other components of the tablet formula.
The glass transition temperature of copolyvidone is relatively low, which allows it to deform and bond with its adjacent particles when compressed, making it an excellent dry binder. This product also undergoes good plastic deformation when compressed, and the resulting tablets and particles have no recovery stress, so they have long-term stability.
Excellent functional additives
About the copovidone structure, Copovidone VA 64 has a lower glass transition temperature than K30 and is less hygroscopic, so the amount of copolyvidone used is about 5%-50% of the total solids to improve the performance and reliability of the selected system, such as improving the plasticity of cellulose film and reducing cracks or fragments even without using plasticizers.
POVIDONE is a thermally initiated polymerization of NVP at 140°C or higher. When NVP and peroxide are heated to 110°C, polymerization occurs quickly, and the reaction temperature rises to 110-190°C on its own, generating a molten polymer. After cooling, it is crushed to form a hygroscopic polymer powder.
Copovidone is an analog of povidone. Copovidone uses as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier. Learn more about copovidone vs crospovidone.
Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.
Copovidone VA64 are vinylpyrrolidone-vinyl acetate copoly-mers which are soluble both in water and in alcohols. They are well-known by their monographic name "Copovidone" or "Copolyvidone". In the pharmaceuticalindustry they are widely used as dry and wet binder in tablets, as flm forming agent or in retard formulations. A major application of Copovidone VA64 is as matrix in amorphous solid dispersions. Learn more about the copovidone solubility now!
